Muscle relaxation is impaired in dystonia: A reaction time study
Identifieur interne : 001A16 ( Main/Corpus ); précédent : 001A15; suivant : 001A17Muscle relaxation is impaired in dystonia: A reaction time study
Auteurs : Alessandro Buccolieri ; Laura Avanzino ; Lucio Marinelli ; Carlo Trompetto ; Roberta Marchese ; Giovanni AbbruzzeseSource :
- Movement Disorders [ 0885-3185 ] ; 2004-06.
English descriptors
Abstract
A simple visual reaction time (RT) paradigm was used to investigate whether the velocity of relaxation is impaired in dystonia. In 16 subjects with a clinical diagnosis of adult‐onset focal, segmental or multifocal dystonia and in 15 age‐matched normal controls, the relaxation reaction time (R‐RT) and the contraction reaction time (C‐RT) were compared across different tasks involving the flexor carpi radialis (FCR), biceps brachii (BB) and triceps brachii (TR) arm muscles. In normal controls, the latency of EMG termination (R‐RT) was significantly shorter than the latency of electromyographic (EMG) onset (C‐RT) in the BB and TR muscles, but not in the FCR muscle. In dystonic patients, the latency of EMG termination (R‐RT) was significantly longer than the latency of EMG onset (C‐RT) in the FCR and BB muscles. No significant difference of the C‐RT was observed between patients and controls whereas the R‐RT was prolonged significantly in the BB and TR muscles of patients with dystonia and almost significantly in the FCR muscle. This study indicates that muscle relaxation is abnormal in patients with focal (multifocal or segmental) dystonia. The impaired muscle relaxation may contribute to the longer overlap of agonist–antagonist activities (co‐contraction) typically observed in dystonia and to the slowness of voluntary movement sequencing. © 2004 Movement Disorder Society
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DOI: 10.1002/mds.10711
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ISTEX:B2630A77E7B74E3BD5C59298F14E089CC8BC6A9CLe document en format XML
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last="Buccolieri">Alessandro Buccolieri</name><affiliation><mods:affiliation>Department of Neurosciences, Ophthalmology and Genetics, Section of Neurology, Movement Disorder Unit, University of Genoa, Genoa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Avanzino, Laura" sort="Avanzino, Laura" uniqKey="Avanzino L" first="Laura" last="Avanzino">Laura Avanzino</name><affiliation><mods:affiliation>Department of Neurosciences, Ophthalmology and Genetics, Section of Neurology, Movement Disorder Unit, University of Genoa, Genoa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Marinelli, Lucio" sort="Marinelli, Lucio" uniqKey="Marinelli L" first="Lucio" last="Marinelli">Lucio Marinelli</name><affiliation><mods:affiliation>Department of Neurosciences, Ophthalmology and Genetics, Section of Neurology, Movement Disorder Unit, University of Genoa, Genoa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Trompetto, Carlo" 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Italy</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. 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In 16 subjects with a clinical diagnosis of adult‐onset focal, segmental or multifocal dystonia and in 15 age‐matched normal controls, the relaxation reaction time (R‐RT) and the contraction reaction time (C‐RT) were compared across different tasks involving the flexor carpi radialis (FCR), biceps brachii (BB) and triceps brachii (TR) arm muscles. In normal controls, the latency of EMG termination (R‐RT) was significantly shorter than the latency of electromyographic (EMG) onset (C‐RT) in the BB and TR muscles, but not in the FCR muscle. In dystonic patients, the latency of EMG termination (R‐RT) was significantly longer than the latency of EMG onset (C‐RT) in the FCR and BB muscles. No significant difference of the C‐RT was observed between patients and controls whereas the R‐RT was prolonged significantly in the BB and TR muscles of patients with dystonia and almost significantly in the FCR muscle. This study indicates that muscle relaxation is abnormal in patients with focal (multifocal or segmental) dystonia. The impaired muscle relaxation may contribute to the longer overlap of agonist–antagonist activities (co‐contraction) typically observed in dystonia and to the slowness of voluntary movement sequencing. © 2004 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Alessandro Buccolieri MD</name><affiliations><json:string>Department of Neurosciences, Ophthalmology and Genetics, Section of Neurology, Movement Disorder Unit, University of Genoa, Genoa, Italy</json:string></affiliations></json:item><json:item><name>Laura Avanzino MD</name><affiliations><json:string>Department of Neurosciences, Ophthalmology and Genetics, Section of Neurology, Movement Disorder Unit, University of Genoa, Genoa, Italy</json:string></affiliations></json:item><json:item><name>Lucio Marinelli MD</name><affiliations><json:string>Department of Neurosciences, Ophthalmology and Genetics, Section of Neurology, Movement Disorder Unit, University of Genoa, Genoa, Italy</json:string></affiliations></json:item><json:item><name>Carlo Trompetto MD</name><affiliations><json:string>Department of Neurosciences, Ophthalmology and Genetics, Section of Neurology, Movement Disorder Unit, University of Genoa, Genoa, Italy</json:string></affiliations></json:item><json:item><name>Roberta Marchese MD</name><affiliations><json:string>Department of Neurosciences, Ophthalmology and Genetics, Section of Neurology, Movement Disorder Unit, University of Genoa, Genoa, Italy</json:string></affiliations></json:item><json:item><name>Giovanni Abbruzzese MD</name><affiliations><json:string>Department of Neurosciences, Ophthalmology and Genetics, Section of Neurology, Movement Disorder Unit, University of Genoa, Genoa, Italy</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>dystonia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>reaction time</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>muscle relaxation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>inhibitory mechanisms</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>sensorimotor integration</value></json:item></subject><articleId><json:string>MDS10711</json:string></articleId><language><json:string>eng</json:string></language><abstract>A simple visual reaction time (RT) paradigm was used to investigate whether the velocity of relaxation is impaired in dystonia. In 16 subjects with a clinical diagnosis of adult‐onset focal, segmental or multifocal dystonia and in 15 age‐matched normal controls, the relaxation reaction time (R‐RT) and the contraction reaction time (C‐RT) were compared across different tasks involving the flexor carpi radialis (FCR), biceps brachii (BB) and triceps brachii (TR) arm muscles. In normal controls, the latency of EMG termination (R‐RT) was significantly shorter than the latency of electromyographic (EMG) onset (C‐RT) in the BB and TR muscles, but not in the FCR muscle. In dystonic patients, the latency of EMG termination (R‐RT) was significantly longer than the latency of EMG onset (C‐RT) in the FCR and BB muscles. No significant difference of the C‐RT was observed between patients and controls whereas the R‐RT was prolonged significantly in the BB and TR muscles of patients with dystonia and almost significantly in the FCR muscle. This study indicates that muscle relaxation is abnormal in patients with focal (multifocal or segmental) dystonia. 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In 16 subjects with a clinical diagnosis of adult‐onset focal, segmental or multifocal dystonia and in 15 age‐matched normal controls, the relaxation reaction time (R‐RT) and the contraction reaction time (C‐RT) were compared across different tasks involving the flexor carpi radialis (FCR), biceps brachii (BB) and triceps brachii (TR) arm muscles. In normal controls, the latency of EMG termination (R‐RT) was significantly shorter than the latency of electromyographic (EMG) onset (C‐RT) in the BB and TR muscles, but not in the FCR muscle. In dystonic patients, the latency of EMG termination (R‐RT) was significantly longer than the latency of EMG onset (C‐RT) in the FCR and BB muscles. No significant difference of the C‐RT was observed between patients and controls whereas the R‐RT was prolonged significantly in the BB and TR muscles of patients with dystonia and almost significantly in the FCR muscle. This study indicates that muscle relaxation is abnormal in patients with focal (multifocal or segmental) dystonia. 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In 16 subjects with a clinical diagnosis of adult‐onset focal, segmental or multifocal dystonia and in 15 age‐matched normal controls, the relaxation reaction time (R‐RT) and the contraction reaction time (C‐RT) were compared across different tasks involving the flexor carpi radialis (FCR), biceps brachii (BB) and triceps brachii (TR) arm muscles. In normal controls, the latency of EMG termination (R‐RT) was significantly shorter than the latency of electromyographic (EMG) onset (C‐RT) in the BB and TR muscles, but not in the FCR muscle. In dystonic patients, the latency of EMG termination (R‐RT) was significantly longer than the latency of EMG onset (C‐RT) in the FCR and BB muscles. No significant difference of the C‐RT was observed between patients and controls whereas the R‐RT was prolonged significantly in the BB and TR muscles of patients with dystonia and almost significantly in the FCR muscle. This study indicates that muscle relaxation is abnormal in patients with focal (multifocal or segmental) dystonia. The impaired muscle relaxation may contribute to the longer overlap of agonist–antagonist activities (co‐contraction) typically observed in dystonia and to the slowness of voluntary movement sequencing. © 2004 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Muscle relaxation is impaired in dystonia: A reaction time study</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Muscle Relaxation in Dystonia</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Muscle relaxation is impaired in dystonia: A reaction time study</title></titleInfo><name type="personal"><namePart type="given">Alessandro</namePart><namePart type="family">Buccolieri</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurosciences, Ophthalmology and Genetics, Section of Neurology, Movement Disorder Unit, University of Genoa, Genoa, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Laura</namePart><namePart type="family">Avanzino</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurosciences, Ophthalmology and Genetics, Section of Neurology, Movement Disorder Unit, University of Genoa, Genoa, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lucio</namePart><namePart type="family">Marinelli</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurosciences, Ophthalmology and Genetics, Section of Neurology, Movement Disorder Unit, University of Genoa, Genoa, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Carlo</namePart><namePart type="family">Trompetto</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurosciences, Ophthalmology and Genetics, Section of Neurology, Movement Disorder Unit, University of Genoa, Genoa, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Roberta</namePart><namePart type="family">Marchese</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurosciences, Ophthalmology and Genetics, Section of Neurology, Movement Disorder Unit, University of Genoa, Genoa, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Giovanni</namePart><namePart type="family">Abbruzzese</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurosciences, Ophthalmology and Genetics, Section of Neurology, Movement Disorder Unit, University of Genoa, Genoa, Italy</affiliation><description>Correspondence: University of Genoa, Via de Toni 5, 16132 Genoa, Italy</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2004-06</dateIssued><dateCaptured encoding="w3cdtf">2003-07-16</dateCaptured><dateValid encoding="w3cdtf">2003-10-15</dateValid><copyrightDate encoding="w3cdtf">2004</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="tables">1</extent><extent unit="references">30</extent><extent unit="words">5329</extent></physicalDescription><abstract lang="en">A simple visual reaction time (RT) paradigm was used to investigate whether the velocity of relaxation is impaired in dystonia. In 16 subjects with a clinical diagnosis of adult‐onset focal, segmental or multifocal dystonia and in 15 age‐matched normal controls, the relaxation reaction time (R‐RT) and the contraction reaction time (C‐RT) were compared across different tasks involving the flexor carpi radialis (FCR), biceps brachii (BB) and triceps brachii (TR) arm muscles. In normal controls, the latency of EMG termination (R‐RT) was significantly shorter than the latency of electromyographic (EMG) onset (C‐RT) in the BB and TR muscles, but not in the FCR muscle. In dystonic patients, the latency of EMG termination (R‐RT) was significantly longer than the latency of EMG onset (C‐RT) in the FCR and BB muscles. No significant difference of the C‐RT was observed between patients and controls whereas the R‐RT was prolonged significantly in the BB and TR muscles of patients with dystonia and almost significantly in the FCR muscle. This study indicates that muscle relaxation is abnormal in patients with focal (multifocal or segmental) dystonia. The impaired muscle relaxation may contribute to the longer overlap of agonist–antagonist activities (co‐contraction) typically observed in dystonia and to the slowness of voluntary movement sequencing. © 2004 Movement Disorder Society</abstract><subject lang="en"><genre>Keywords</genre><topic>dystonia</topic><topic>reaction time</topic><topic>muscle relaxation</topic><topic>inhibitory mechanisms</topic><topic>sensorimotor integration</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Brief Report</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>19</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>681</start><end>687</end><total>6</total></extent></part></relatedItem><identifier type="istex">B2630A77E7B74E3BD5C59298F14E089CC8BC6A9C</identifier><identifier type="DOI">10.1002/mds.10711</identifier><identifier type="ArticleID">MDS10711</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2004 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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